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Peptides libraries

Peptides librairies

Eurogentec offers custom peptide libraries, available with several modifications, in a 96-well plate format for high-throughput screening purpose.

Peptide librairie type

Peptide library type. A. Overlapping peptide sequences which are based on a larger protein sequence (peptide length and number of amino acid overlap must be provided). B. Unrelated peptides of different lengths. C. Alanine scanning where each amino acid position of the peptide is replaced with alanine. D. Degenerated Mix where at position X, a mixture of amino acids is used for coupling (customer specifies amino acids and %). The resulting peptides are mixtures, therefore not purifiable.

Peptides libraries specification

Quantity: 200 - 500 μg of each peptide (up to 10 mg on request) - Minimum 24 peptides
Format: 96-well
Type: Unbound, free crude peptides – Amino N-terminus- CONH2 C-terminus by default (COOH on request for additional fee)
Length: 5-22 amino acids
QC validation: MALDI-TOF QC on 10 % of peptides

Peptides libraries benefits

  • Superior technical design assistance upon request
  • Peptide lengths as long as 22-mers
  • Modifications such as fluorescent labelling or biotinylation
  • Cost effective

Application of peptide libraries

Epitope mapping

Epitopes recognised by antibodies are commonly 6 amino acids in length. By generating overlapping 15-mers peptides, each shifted by 4 amino acids, one can unequivocally determine which amino acids make up the epitope (fig. 1 A). Eurogentec proposes this service (see Epitope Mapping in the Eurogentec Antibodies brochure).

T-Cell stimulation

Libraries can also be generated to see which particular peptide from an antigenic protein is responsible for a T-cell response. The design process is similar to the epitope mapping example above.

Alanine scanning

By screening peptides with systematic replacement of each amino acid with alanine, one can determine to which extent a particular amino acid is required and sufficient for an interaction or an activity (fig 1 C).

Amino Acid optimisation

By systematically replacing every amino acid position in a peptide with each possible amino acid, one can optimise the activity of a particular peptide sequence (fig 1 D).

  • Protein-protein and protein-peptide interaction studies
  • Kinase motif discovery
  • Protease motif discovery
  • Biological Assays

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