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LABEL LICENSE STATEMENTS

NOTICE TO PURCHASER: LIMITED LICENSES

Latest amendment: 13 NOVEMBER 2018



1. For Roche Enzyme Products Conveying Polymerase Patent Rights, Chemically-Modified Hot-Start Polymerase Reagents and Kits, Licensed dsDNA-Binding Dye Research Kits and Licensed 5’ Nuclease Research Kits

NOTICE TO PURCHASER: LIMITED LICENSE

Use of this product is covered by applicable US patents and corresponding patent claims outside the US held by Roche. The purchase of this product includes a limited, non-transferable immunity from suit under such patent claims for using only this amount of product for the purchaser’s own internal research. No right under any other patent claim, no right to perform any patented method, and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser's activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel. This product is for research use only. Additional rights for use in non-diagnostic fields require a license from Life Technologies. Diagnostic uses require a separate license from Roche. Further information on purchasing licenses may be obtained by contacting Out-licensing at Thermo Fisher Scientific, 5791 Van Allen Way, Carlsbad California 92008; outlicensing@lifetech.com.

2. For products subject to Section 2.17(d) that could be confused with licensed royalty-bearing products and that do not convey necessary patents rights for the expired 5’ Nuclease Process and/or dsDNA-Binding Dye Process:

NOTICE TO PURCHASER: DISCLAIMER OF LICENSE

No license is conveyed with the purchase of this product under any of US Patents Nos. 5,804,375, 5,994,056, 6,171,785, 5,538,848, 5,723,591, 5,876,930, 6,030,787, and 6,258,569, and corresponding patents outside the United States, or any other patents or patent applications, relating to the 5’ Nuclease and dsDNA-Binding Dye Processes. For further information contact Outlicensing at Thermo Fisher Scientific, 5791 Van Allen Way, Carlsbad California 92008; outlicensing@lifetech.com.

3. RNA interference

RNA interference is licensed under European Patents 1144623, 1214945 and foreign equivalents from Alnylam Pharmaceuticals, Inc., Cambridge, USA and is provided only for use in academic and commercial research (excluding the evaluation or characterization of this product as the potential basis for a siRNA-based drug) and not for any other commercial purposes. Information about licenses for commercial use (including discovery and development of siRNA-based drugs) is available from Alnylam Pharmaceuticals, Inc., 300 Third Street, Cambridge, MA 02142, USA.

4. Elitech Dyes and Quenchers

Use of this product (including but not limited to Yakima Yellow® and Eclipse™ Dark Quencher) is covered by patents owned by ELITechGroup, Inc., including but not limited to the following US patents and corresponding patent claims outside the US: US 6,699,975, US 6,790,945, US 7,662,942, US 6,653,473, US 6,972,339, 7,541,454, 7,671,218, 7,767,834, 8,163,910, 6,727,356. This product, including both Research Grade Product and IVD Grade Product, is sold under a licensing arrangement with ELITechGroup, Inc. for the purchaser’s own internal research. Commercial use of this product requires a separate license from Kaneka Eurogentec S.A. Further information on purchasing licenses may be obtained by contacting licensing@eurogentec.com.

5. Custom Molecular Beacon Probes

The use of Custom Molecular Beacon Probes employs the following patent rights licensed to Kaneka Eurogentec S.A. from The Public Health Research Institute of the City of New York: (a) the claims of U.S. Patent Application Serial No. 08/439,819; (b) the claims of U.S. Patent Application Serial No. 08/990,176; and (c) all patent application claims and all patent claims, U.S. and foreign, that cover improvements in the foregoing claimed probes, kits and assays and whose subjects are inventions and discoveries that are made by the Public Health Research Institute of New York. The use of Custom Molecular Beacon Probes is limited to the field of use comprising the internal use by an end user of a product solely in assays of the end user (or in applications of the end user’s customer, if the end user is performing contract research) in scientific research and development.

6. LNA® oligonucleotides

LNA® oligonucleotides produced under license from Exiqon A/S for research use only. Not for resale or for therapeutic use or use in humans.

7. UDG

Use of UDG employs patent rights licensed from Invitrogen Corporation.

8. SYBR® Green I nucleic acid gel stain

This product is provided under a technology agreement from Life Technologies Corporation to Kaneka Eurogentec S.A. The sale of this product is conditioned on the buyer using the product only in research conducted by the buyer and not to sell or otherwise commercialise this product or its components (1) in manufacturing; (2) to provide a service, information, or data in exchange for payment; (3) for therapeutic, diagnostic or prophylactic purposes; or (4) for resale, not even if resold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com.

9. Alexa Fluor®, BODIPY®, Cascade Blue®, Marina Blue®, Oregon Green®, Pacific Blue™, QSY®, Rhodamine Red™ Texas Red® dyes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

10. Black Hole Quencher®

Black Hole Quencher® and BHQ® are registered trademarks of Biosearch Technologies, Inc., Novato, California, U.S.A. (‘BTI’) Patents are currently pending for the BHQ technology and such BHQ technology is licensed by the manufacturer pursuant to an agreement with BTI and these products are sold exclusively for research and development use only. They may not be used for human or veterinary in vitro or clinical diagnostic purposes and they may not be re-sold, distributed or re-packaged. For information on licensing programs to permit use for human or veterinary in vitro or clinical diagnostic purposes, please contact Biosearch at licensing@biosearchtech.com.

11. CAL Fluor™ and Quasar™

CAL Fluor™ and Quasar™ dyes are trademarks of Biosearch Technologies, Inc., Novato, California, U.S.A. (‘BTI’). Patents are currently pending for the CAL Fluor™ and Quasar™ dye technology and such CAL Fluor™ and Quasar™ dye technology is licensed pursuant to an agreement with BTI and these products are sold exclusively for research and development use only. They may not be used for clinical or diagnostic purposes and they may not be re-sold, distributed or re-packaged.

12. Iso-base containing oligonucleotides

Iso-base containing oligonucleotides are covered by US Patents 6,001,983, 6,037,120, and 6,140,496 and their foreign counterparts, and licensed to Kaneka Eurogentec S.A. by EraGen Biosciences, Inc.

13. C-5 Propyne and G-clamp modified oligonucleotides

C-5 Propyne and G-clamp modified oligonucleotides are covered by patents or patents pending owned by Isis Pharmaceuticals, Inc. (“Isis”). Purchase of this product includes a limited license to use this product solely for internal research. This license specifically excludes (and you have no right to use this product for): (a) therapeutic or diagnostic applications (including products or services that incorporate this product), (b) any in vivo toxicity/safety study in support of an investigational new drug application (or foreign counterpart), (c) resale (including sale of any products or services that incorporate this product) or (d) gene functionalization activities (including products or services that incorporate data derived from gene functionalization activities) if such activities have commercial application, any and all of which require a separate license from Isis. Neither this product nor any product created through its use may be used in human clinical trials. In the event you have a separate agreement with Isis regarding this product which explicitly states that the foregoing is not applicable to you, your use of this product will be governed by the terms of such agreement. In no event does the limited license included with the purchase of this product expand or alter the scope of the license granted pursuant to such agreement.

14. PNA

All custom PNA oligomers sold by Kaneka Eurogentec are manufactured by Panagene under an exclusive license and to be used for internal research only. And such custom PNA oligomers are not to be resold unless properly licensed to do so by separate license. All custom PNA oligomers are made and sold pursuant to license under one or more of US Patents Nos. US 5,773,571, 6,133,444, US 6,172,226, US 6,395,474, US 6,414,112, US 6,613,873, US 6,710,163 and US 6,713,602, or corresponding patent claims outside the US.

15. Probes

Use of this product is covered by one or more of the following US patents and corresponding patent claims outside the US: 5,538,848, 5,723,591, 5,876,930, 6,030,787, 6,258,569 and 5,804,375 (claims 1-12 only). The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser’s own internal research. Except under separate license rights available from Applied Biosysterns, no right under any other patent claim, or to perform commercial services of any kind, including without limitation reporting the results of purchaser’s activities for a fee or other commercial consideration, or to sublicense, repackage with other products, or resell in any form, is conveyed expressly, by implication, or by estoppel. This product is for research use only. Diagnostic uses under Roche patents require a separate license from Roche. Further information on purchasing licenses may be obtained from the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.

16. Dual-labeled probes or products containing dual-labeled probes that are not Licensed Probes :

No license is conveyed with the purchase of this product under any of US Patents Nos. 5,804,375, 5,994,056, 6,171,785, 5,538,848, 5,723,591, 5,876,930, 6,030,787, and 6,258,569, and corresponding patents outside the United States, or any other patents or patent applications, relating to the 5’ Nuclease and dsDNA-Binding Dye Processes. For further information contact the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.

17. Products that are not Henco-Only Products

The purchase of this product includes a limited, non-transferable license for all fields other than human or veterinary in vitro diagnostics under specific claims of U.S. Patent Nos. 6,174,670, 6,569,627 and 5,871,908, owned by the University of Utah Research Foundation or Evotec Biosystems GmbH and licensed to Idaho Technology, Inc. and Roche Diagnostics GmbH, to use only the enclosed amount of product according to the specified protocols. No right is conveyed, expressly, by implication, or by estoppel, to use any instrument or system under any claim of U.S. Patent Nos. 6,174,670, 6,569,627 and 5,871,908, other than for the amount of product contained herein.

18. Henco-Only Products

The purchase of this product includes a limited, non-transferable license for all fields other than human or veterinary in vitro diagnostics under U.S. Patent No. 5,871,908, owned by Evotec Biosystems GmbH and licensed to Roche Diagnostics GmbH, to use only the enclosed amount of product according to the specified protocols. No right is conveyed, expressly, by implication, or by estoppel, to use any instrument or system under any claim of U.S. Patent No. 5,871,908, other than for the amount of product contained herein.

19. Rox Passive Reference

The purchase of this product includes a limited, non-transferable right to use the purchased amount of the product to perform Applied Biosystems’ patented Passive Reference Method for the purchaser’s own internal research. No right under any other patent claim and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser’s activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel. This product is for research use only. For information about these rights or on obtaining additional rights, please contact outlicensing@lifetech.com or Out Licensing, Life Technologies, 5791 Van Allen Way, Carlsbad, California 92008.

20. For Products that contain a fluorescent dye that could be used as a passive reference but do not meet the definition of Licensed Product (such as a standalone fluorescent dye)

No license is conveyed with the purchase of this product to perform Applied Biosystems’ patented Passive Reference Methods, or under any patents or patent applications, relating to the use of a fluorescent indicator as a passive reference in real time PCR. For information about these rights or on obtaining additional rights, please contact outlicensing@lifetech.com or Out Licensing, Life Technologies, 5791 Van Allen Way, Carlsbad, California 92008.

21. Hilyte™ Fluor Dyes

Use of this product is covered by one or more of the following US patents owned by AnaSpec, Inc.: USP 7,465,810, USP 7,754,893, USP 7,820,783, USP 8,258,292, and divisionals, continuations, continuations-in-part, reissues, substitutes, and extensions thereof. The purchase of this product conveys to the buyer a limited, non-exclusive, nontransferable right (without the right to sell, repackage, or further sublicense) under these patent rights to use only the amount of product purchased for the purchaser’s own internal research. No other license is granted to the buyer whether expressly, by implication, by estoppel or otherwise. In particular, the purchase of this product does not include nor carry any right or license to use, develop, or otherwise exploit this product commercially, and no rights are conveyed to the buyer to use the product or components of the product for any other purposes, including without limitation, provision of services to a third party, generation of commercial databases, or clinical diagnostics or therapeutics. This product is for research use only. For information on purchasing a license to this product for purposes other than research, contact licensing@eurogentec.com.

22. QXL® Quenchers

Use of this product is covered by one or more of the following US patents owned by AnaSpec, Inc.: USP 7,910,753, USP 8,093,411, and divisionals, continuations, continuations-in-part, reissues, substitutes, and extensions thereof. The purchase of this product conveys to the buyer a limited, non-exclusive, nontransferable right (without the right to sell, repackage, or further sublicense) under these patent rights to use only the amount of product purchased for the purchaser’s own internal research. No other license is granted to the buyer whether expressly, by implication, by estoppel or otherwise. In particular, the purchase of this product does not include nor carry any right or license to use, develop, or otherwise exploit this product commercially, and no rights are conveyed to the buyer to use the product or components of the product for any other purposes, including without limitation, provision of services to a third party, generation of commercial databases, or clinical diagnostics or therapeutics. This product is for research use only. For information on purchasing a license to this product for purposes other than research, contact licensing@eurogentec.com.

23. SensoLyte® assays and assay kits

Use of this product is covered by European Patent 1243658, US Patents 7,033,778 and 7,256,013 and their foreign counterparts, and licensed by CycLex Co. Ltd.

24. Apstatin peptide

Use of this product is covered by US Patent No. 5,656,603.

25. FRETS-VWF73 and any kits containing FRETS-VWF73

Use of this product is covered by US Patent 7,718,763 and by Japan Patent 3,944,586, and licensed by the National Cerebral and Cardiovascular Center.

26. Minor Groove Binder and Eclipse™ Dark Quencher

Use of this product is covered by patents owned by ELITechGroup, Inc., including but not limited to the following US patents and corresponding patent claims outside the US: US 6,492,346, US 6,884,584, US 11/784,539, US 7,556,923, US 12/172,999, US-2009-0048427-A1, US 6,084,102, US 6,426,408, US 6,727,356, US 6,790,945, US 6,699,975, US 6,486,308 and US 7,794,945. This product, including both Research Grade Product and IVD Grade Product, is sold under a licensing arrangement with ELITechGroup, Inc. for use by purchaser only in human in vitro diagnostics applications to provide information for individual patient management solely using 5’ nuclease (Taqman-MGB) technology. Commercial use of this product requires a separate license from Kaneka Eurogentec S.A. Further information on purchasing licenses may be obtained by contacting licensing@eurogentec.com.

27. MOE

The use of this product is covered by patents or patents pending owned by Ionis Pharmaceuticals, Inc. ("Ionis"). Purchase of this product includes a limited, non-transferable right to use the purchased amount of the product for the purchaser’s own internal research and does not include any license to use this product for other purpose like (for instance and not exhaustive) : (a) therapeutic or diagnostic applications, (b) any in vivo toxicity/safety study in support of an investigational new drug application (or foreign counterpart), (c) resale (including sale of any products or services that incorporate this product or oligonucleotides) or (d) gene functionalization activities (including products or services that incorporate data derived from gene functionalization activities). Any and all of such application of the oligonucleotides may require a separate license from Ionis.

28. MGB Pleiades Probes

Use of this product is covered by patents owned by ELITechGroup, Inc., including but not limited to the following US patents and corresponding patent claims outside the US: US 6,492,346, US 6,884,584, US 11/784,539, US 7,556,923, US 12/172,999, US-2009-0048427-A1, US 6,084,102, US 6,426,408, US 6,727,356, US 6,790,945, US 6,699,975, US 6,486,308, US 7,794,945 and US 7,381,818. This product, including both Research Grade Product and IVD Grade Product, is sold under a licensing arrangement with ELITechGroup, Inc. for the purchaser’s own internal research. Commercial use of this product requires a separate license from Kaneka Eurogentec S.A. Further information on purchasing licenses may be obtained by contacting licensing@eurogentec.com.


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