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Peptide-oligo conjugates

Peptide-oligo conjugates

Peptide-oligonucleotide conjugates (POC) are molecular composites containing a nucleic acid moiety covalently linked to a polypeptide moiety. They serve many important roles as potential therapeutics and owing to their stability, can resist intracellular enzymes present in different cellular compartments.

Peptide-oligo conjugates

Peptide-oligo conjugates specifications

  • Production quantities: 1-20 mg
  • Typical lead times: 5-6 weeks
  • Peptide length: 5-22 amino acids
  • Oligonucleotide length: 10 - 40 bases
  • Oligonucleotide modifications available:
    • Phosphorothioate linkage
    • Dye labelling (FAM, HEX ,TET, etc)
    • Biotinylation
    • Spacer (C3, HEG, etc)
  • Peptide modifications available:
    • Acetylation
    • Dye-Labelling (FAM, TAMRA)
  • QC Analysis: Mass Spectrometry

Peptide-oligo conjugates applications

  • Oligo therapeutic target via conjugation to a cell permeable peptide, which acts as a cargo carrier of the oligonucleotide.
  • Peptide conjugations to oligos with modifications designed for varied functionalities/applications .

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