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2' O-Me RNA

Backbone (Bases + Linkages)

Oligo-2’ O-Methyl (O-Me) nucleotides are resistant (but not totally resistant) to a variety of ribo- and deoxyribonucleases. As well as being stable to normal handling and nuclease resistant, oligo-2’ O-Me-nucleotides form more stable hybrids with complementary RNA strands than equivalent DNA and RNA sequences.

DescriptionSize Reference USD  
2'O-Me RNA Base 40 nmol scale (10-99 bases) - 1 base1 base BA-2M001-004 7.20Configure...
2'O-Me RNA Base 200 nmol scale(5-139 bases) - 1 base1 base BA-2M001-020 10.80Configure...
2'O-Me RNA Base 1000 nmol scale (5-139 bases) - 1 base1 base BA-2M001-100 15.60Configure...
2'O-Me RNA Base 2.5 µmol scale (5-139 bases) - 1 base1 base BA-2M001-M02 22.80Configure...
2'O-Me RNA Base 5 µmol scale (5-139 bases) - 1 base1 base BA-2M001-M05 39.60Configure...
2'O-Me RNA Base 10 µmol scale (5-139 bases) - 1 base1 base BA-2M001-M10 66.00Configure...
2'O-Me RNA Base 20 µmol scale (5-139 bases) - 1 base1 base BA-2M001-M20 102.00Configure...
* More info on the Purifications page

More info

Oligo-2’ O-Methyl (O-Me) nucleotides are resistant (but not totally resistant) to a variety of ribo- and deoxyribonucleases. As well as being stable to normal handling and nuclease resistant, oligo-2’ O-Me-nucleotides form more stable hybrids with complementary RNA strands than equivalent DNA and RNA sequences. This combination of useful properties promises to make 2’ O-Me-RNA sequences powerful research tools. Conveniently, the synthesis and handling of 2’ O-Me RNA is as simple to perform as DNA synthesis, and avoids most of the problems associated with RNA synthesis.

The combination of properties offered by oligo-2’ O-Me-nucleotides (nuclease resistance, stable hybrid formation, ease of synthesis) make them especially suitable for use as antisense probes. In this mode, RNase H resistant oligo-2’ O-Me-nucleotides, labelled or unlabelled, can be used to block specific RNA functions and, when attached to a suitable tag, usually biotin, can be used in affinity purification of RNA complexes.


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   For Research Use only

Literature & Resources

Product citations


FARIA M. et al., "Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo", Nature Biotechnology, vol. 19, n° 1, p. 40-44, January 2001


DE BACKER M. et al., "An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans", Nature Biotechnology, vol. 19, n° 3, p. 235-241, March 2001


ANGO F. et al., "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer", Nature, n° 411, p. 962-965, 21 June 2001


VAN HEUSDEN J. et al., "Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity", British Journal of Cancer, vol. 86, n° 4, p. 605-611, 12 February 2002


SKORDIS L. et al., "Bifunctional antisense oligonucleotides provide a trans-acting plicing enhancer that stimulates SMN2 gene expression in paient fibroblasts", PNAS, vol. 100, n° 7, p. 4114-4119, April 2003


GROTE K. et al., "Stretch-inducible Expression of the Angiogenic Factor CCN1 in Vascular Smooth Muscle Cells Is Mediated by Egr-1", Journal of Biological Chemistry, vol. 279, n° 53, p. 55675-55681, December 2004

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