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ACTH/Corticotropin Peptides

Catalog Go™ peptides

Corticotropin-releasing factor (CRF), a 41 amino acid-peptide widely distributed in the brain mediates endocrine as well as autonomic and behavioral responses to stress. Its receptor subtypes, CRF-R1 and CRF-R2, are expressed in the brain. CRF is hypersecreted from hypothalamic as well as from extrahypothalamic neurons in depression, resulting in hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and elevations of cerebrospinal fluid concentrations of CRF. This increase in CRF neuronal activity is believed to mediate certain behavioral symptoms of depression involving sleep and appetite disturbances, reduced libido and psychomotor changes. The hyperactivity of CRF neuronal systems appears to be a state marker for depression because HPA axis hyperactivity normalizes following successful antidepressant treatment. The CRF system may play a significant role in the regulation of energy balance. CRF and CRF-related peptides, which elicit their effects through G-protein-coupled receptors known in mammals as CRF1 receptor and CRF2 receptor, are capable of strong anorectic and thermogenic effects. CRF, urocortin and urotensin I share amino acid sequences and they inhibit food intake in mammals.

DescriptionSize Reference USD Qty  
ACTH (1-10) - 5 mg5 mg AS-20624 93.00Add to cart
ACTH (1-17) - 1 mg1 mg AS-60708 71.00Add to cart
ACTH (1-24), human - 1 mg1 mg AS-20613 61.00Add to cart
ACTH (1-24), human - 5 mg5 mg AS-20614 259.00Add to cart
ACTH (1-39), human - 0.5 mg0.5 mg AS-20610 127.00Add to cart
ACTH (1-39), human - 1 mg1 mg AS-20611 215.00Add to cart
ACTH (18-39), human (CLIP) - 1 mg1 mg AS-20619 121.00Add to cart
ACTH (7-38), human - 1 mg1 mg AS-20618 121.00Add to cart
Biotin-ACTH (1-39), human - 0.5 mg0.5 mg AS-23968 225.00Add to cart
Biotin-Corticotropin Releasing Factor, Biotin-CRF, human, rat - 0.5 mg0.5 mg AS-23976 303.00Add to cart
Corticotropin Releasing Factor, CRF, human, rat - 1 mg1 mg AS-24254 190.00Add to cart
Corticotropin Releasing Factor, CRF, ovine - 0.5 mg0.5 mg AS-22932 159.00Add to cart
Sauvagine - 0.5 mg0.5 mg AS-24475 132.00Add to cart


Centrally administered N-terminal fragments of ACTH (1-10, 4-10, 4-9) display convulsant properties in rabbits.
ACTH (18-39) is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine.
Corticotropin-inhibiting peptide (CIP), the 7-38 fragment of human ACTH (1-39), is known to act as an antagonist of ACTH receptors. It does not have any corticosteroidogenic activity.
Sauvagine is a hypotensive and diuretic peptide. Originally isolated from the skin of the frog, Phyllomedusa sauvagei. It affects diuresis in the cardiovascular system and causes the release of ACTH and endorphins.
Urocortin III is a 38 amino acid peptide that is a member of the Corticotropin-Releasing Factor (CRF) family of peptides. Studies show that Urocortin III is highly selective for the Corticotropin-Releasing Factor 2 (CRF2) receptor and does not show affinity for the CRF binding protein

Reference Name Sequence MW (Da)
AS-20624 ACTH (1-10) SYSMEHFRWG 1299,4
AS-20613/20614 ACTH (1-24), human SYSMEHFRWGKPVGKKRRPVKVYP 2933,5
AS-20619 ACTH (18-39), human (CLIP) RPVKVYPNGAEDESAEAFPLEF 2465,7
AS-22932 Corticotropin Releasing Factor, ovine SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH2 4670,4
AS-23976 Biotin-Corticotropin Releasing Factor, human, rat Biotin-SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2 4984,8

* This sequence is also known as joining peptide, one of the major products of proopiomelanocortin (POMC). Isolated from bovine posterior pituitary, this peptide possesses Na pump inhibitor activity.

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