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Anti-Proteolipid Protein (PLP) IgG Quantitative ELISA Kits

iD Sensolyte® Assay Kits

Proteolipid protein (PLP) is the most abundant protein in the central nervous system (CNS) myelin sheath and is highly conserved among species. PLP has a 50% hydrophobic amino acids content and a molecular weight of 30 kDa. Mouse PLP is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. 

Autoantibody response to mouse PLP (139-151) has been observed in induced experimental autoimmune encephalomyelitis (EAE) in SJL, F1, and SWR mice strains. Autoantibody response to mouse PLP (178-191) has been observed in induced experimental autoimmune encephalomyelitis (EAE) in B10.PL, SJL, C57BL/6, F1, and BALB/c mice strains . However, the exact pathological role and action of anti-mouse PLP autoantibody is not well understood. 

The SensoLyte® Anti-PLP IgG Quantitative ELISA Kits (mouse) provide a convenient and quantitative assay for anti-PLP (139-151 or 178-191) autoantibody in mouse. This kit is useful to researchers who want to determine the amount of anti-PLP (139-151 or 178-191) antibody present in biological samples, and can help provide information on the role it plays in the development and treatment of EAE, an animal model for MS pathogenesis.

DescriptionSize Reference USD Qty  
SensoLyte® Anti-PLP (139-151) IgG Quantitative ELISA Kit (mouse) *Colorimetric* - 1 kit1 kit AS-55524 457.00Add to cart
SensoLyte® Anti-PLP (178-191) IgG Quantitative ELISA Kit (mouse) *Colorimetric* - 1 kit1 kit AS-55523 457.00Add to cart


Proteolipid protein (PLP) is the most abundant protein in the central nervous system (CNS) myelin sheath and is highly conserved among species. Mouse PLP (139-151) and PLP (178-191) are able to induce autoantibody production and cause extensive plaque-like demyelination. However, the exact pathological role and action of anti-mouse PLP (139-151) and anti-PLP (178-191) autoantibody is not well understood.

Benefits



• Convenient Format: - Pre-coated and pre-blocked 96-well strip plate
- Ready-to-use substrate solutions and other assay components
• Minimal Sample Size: - Requires only 0.5-1 μl of serum or cerebrospinal fluid to perform the assay
• High Sensitivity: - Detects as low as 100 pg of anti-PLP
(139-151 or 178-191) IgG without cross-reactivity between each other
• Broad Dynamic Range: - Detection of 8 to 500 ng antibody/ml serum


Description

λ
Detection
Biological sample volume Lowest Detection Limit  Kit contains Assay time # of
assays in
96-well plate
PLP (Proteolipid protein) ELISA Kit
SensoLyte® Anti - PLP (139 - 151) IgG Quantitative ELISA Kit (Mouse)  Colorimetric 450 8-500 ng/ml 100 pg • PLP (139-151) coated and BSA blocked 8-well strips 12 x 8 strips
• Mouse anti-PLP (139-151) IgG Standard
• 1X Sample Dilution Buffer
• 10X Wash Buffer
• TMB color substrate solution
• Stop Solution
• Secondary antibody, Goat anti-Mouse IgG-HRP
2-3 hours 1 x 96 well plate
(80 assays)
SensoLyte® Anti - PLP (178 - 191) IgG Quantitative ELISA Kit (Mouse)  Colorimetric 450 8-500 ng/ml 100 pg

• PLP (178-191) coated and BSA blocked 8-well strips 12 x 8 strips
• Mouse anti-PLP (178-191) IgG Standard
• 1X Sample Dilution Buffer
• 10X Wash Buffer
• TMB color substrate solution
• Stop Solution
• Secondary antibody, Goat anti-Mouse IgG-HRP

2-3 hours 1 x 96 well plate
(80 assays)
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