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Beta-Secretase 1 (BACE1) Assay kit

iD Sensolyte® Assay Kits

β-Secretase is a membrane-anchored aspartic protease existing in acidic subcellular vesicles. It is a key player in producing β-amyloid peptides through proteolytic cleavage of the β-amyloid precursor protein (APP). Accumulation of neurotoxic β-amyloid peptide is seen in senile plaques in the brains of patients with Alzheimer's disease (AD), an age-related cognitive disorder. Therefore, targeting β-secretase is considered a potential therapeutic strategy for the prevention and treatment of AD.

The SensoLyte® 520 β-Secretase Assay Kit is a homogeneous assay that can be used to detect the activity of enzyme and for screening of secretase inhibitors. It contains a QXL® 520/ HiLyte Fluor(tm) 488 FRET substrate. The sequence of this FRET peptide is derived from the β-secretase cleavage site on the Swedish APP mutation. This mutation causes the enhancement of β-secretase to process APP, resulting in an early onset of AD. Active β-secretase cleaves FRET substrate into two separate fragments resulting in the release of HiLyte Fluor(tm) 488 fluorescence that can be monitored at excitation/emission= 490/520 nm. The long wavelength fluorescence of HiLyte Fluor(tm) 488 is less interfered by the autofluorescence of components in biological samples and test compounds.

DescriptionSize Reference USD Qty  
SensoLyte® 520 b-Secretase (BACE1) Activity Assay Kit *Fluorimetric* - 1 kit1 kit AS-71144 504.00Add to cart
  • Convenient format: The kit provides ample reagents to perform 100 assays in a 96-well plate format
  • High Speed: The entire process can be completed in one hour
  • Assured Reliability: Detailed protocol and references are provided
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