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C3A Peptides

Catalog Go™ peptides

The C3a anaphylatoxin is a 78-amino-acid peptide derived from the proteolytic cleavage of the complement protein C3. It mediates a variety of proinflammatory and immunoregulatory functions through its binding to the seven-transmembrane segment G-protein-coupled C3a receptor (C3aR). C3a induces smooth muscle contraction, increases vascular permeability, arachidonic acid metabolism, cytokine release, cellular degranulation and chemotaxis. C3a are involved in microbial host defense, immune regulation and protection against toxic insult. C3a enhance granulocyte adhesion to endothelial and epithelial cell monolayers. Anaphylatoxin C3a inhibits the generation of leukocyte inhibitory factor activity by human mononuclear leukocytes and T lymphocytes cultured with the mitogens in-vitro.


DescriptionSize Reference USD Qty  
[Trp63, 64]-C3a (63-77) - 1 mg1 mg AS-61119 105.00Add to cart
C3a (70-77) - 1 mg1 mg AS-61118 39.00Add to cart
Reference Name Sequence MW (Da)
AS-61119 [Trp63, 64]-C3a (63-77) WWGKKYRASKLGLAR 1820,2
AS-61118 C3a (70-77) ASHLGLAR 823,9
Reference Name Description
AS-61119 [Trp63, 64]-C3a (63-77)  
AS-61118 C3a (70-77) C-terminal fragment of the C3a anaphylatoxin peptide. It causes contraction of rodent ileum and uterus, release of vasoactive amines from rat mast cells, and increases vascular permeability in guinea pig and human skin. Both purified C3a and synthetic C3a (70-77), which retains  partially the activity of anaphylatoxin, are shown to interact directly with human lymphocytes.
AS-62910 C3f fragment, Human c3 (1286-1297) This is amino acids 1286 to 1297 fragment of the third component of human c3, a part of human complement containing the HWESAS motif. This peptide is a fragment of the complement C3f peptide. It is a biomarker used in mass spectrometry (MS) in cancer studies. Its level was increased in some cancer patents sera.
AS-62909 C3f, Human c3 (1282-1298) This is amino acids 1282 to 1298 fragment of the third component of human c3, a part of human complement containing the HWESAS motif. C3-convertase catalyzes the proteolytic cleavage of C3 into C3a and C3b as a part of the classical complement system. The C3f fragment is produced by the proteolytic cleavage of C3b. It is a potential biomarker in cancer research.
AS-61857 Complement anaphylatoxin C5a (37-53), human This peptide is a complement C5a anaphylatoxin fragment 37 to 53 residues of the 74-aa peptide generated from the fifth component of complement (C5) during complement activation. C5a acts as an anaphylatoxin, stimulating  leukocytes and endothelial cells, and is a chemotactic factor for neutrophils and other inflammatory cells. This peptide is an antisense homology box (AHB) peptide of C5a. 
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