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M-Z (Cancer Research)

Cancer Research Peptides

Antigens encoded by MAGE genes

Antigens encoded by MAGE genes are of particular interest for cancer immunotherapy because of their strict tumoral specificity and because they are shared by many tumors. 

MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells. Therefore, the antigens encoded by MAGE-type genes are strictly tumor specific and common to many tumors. Among the MAGE genes, MAGE-3 is one of the most frequently expressed in tumors. For instance, it is expressed in 76% of metastatic melanomas. 

MAGE-A4 belongs to the family of genes that are specifically expressed in a variety of tumors. MAGE-A4-derived peptides are presented by MHC molecules at the cell surface to cytotoxic T-lymphocytes. Because the HLA-A*0201:MAGE-A4 complex occurs only on tumor cells, it is considered to be an appropriate target for immunotherapy. 

MAGE-A1 tumor antigen can fully activate the mouse peptide-specific CTL lines to produce IFN-gamma. Tumor-specific shared antigens, such as those of the MAGE gene family, are expressed by tumors of different histological types.


PD-L1

Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism.

Human PD-L1 inhibitors are peptide-based molecules. They bind to human PD-1 and inhibit PD-1/PD-L1 binding. These peptides have anchor residues that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.

DescriptionSize Reference USD Qty  
5-FAM-PMDM61 mg AS-63359-1- 291.00Add to cart
a-Tubulin (29-50) K40(Ac)-WGK, biotin1 mg AS-65411-1 340.00Add to cart
c-Myc peptide epitope1 mg AS-24194 22.00Add to cart
c-Myc peptide epitope5 mg AS-20590 99.00Add to cart
Human PD-L1 inhibitor I1 mg AS-65581 155.00Add to cart
Human PD-L1 inhibitor II1 mg AS-65582 155.00Add to cart
Human PD-L1 inhibitor III1 mg AS-65583 155.00Add to cart
Human PD-L1 inhibitor IV1 mg AS-65584 190.00Add to cart
Human PD-L1 inhibitor V1 mg AS-65585 110.00Add to cart
MAGE-3 (271-279)1 mg AS-61355 44.00Add to cart
Noxa A BH3 peptide, cell permeable1 mg AS-64087 303.00Add to cart
Nuclear Factor (Erythroid-derived 2) like 2, Nrf2 (74-87)5 mg AS-65341 280.00Add to cart
NY-ESO-1 (87-111)1 mg AS-62655 198.00Add to cart
Shepherdin (79–87)1 mg AS-62748 71.00Add to cart
TRP-2, Tyrosinase-related Protein 2 (180-188)1 mg AS-61058 93.00Add to cart
TRP-2, Tyrosinase-related Protein 2 (181-188)1 mg AS-64811 71.00Add to cart
Tyrosinase (368-376) [Asp370]1 mg AS-61456 110.00Add to cart
Reference Name Sequence MW (Da)
AS-65411 a-Tubulin (29-50) K40(Ac)-WGK, biotin Ac-GIQPDGQMPSD-K(ac)-TIGGGDDSFNWG-K(biotin) 2918,2
AS-24194 c-Myc peptide epitope EQKLISEEDL 1203,3
AS-20590 c-Myc peptide epitope EQKLISEEDL 1203,3
AS-65581 Human PD-L1 inhibitor I FNWDYSWKSERLKEAYDL 2350.7
AS-65582 Human PD-L1 inhibitor II FNWDYSLEELREKAKYK 2219.6
AS-65583 Human PD-L1 inhibitor III TEKDYRHGNIRMKLAYDL 2223.7
AS-65584 Human PD-L1 inhibitor IV GNWDYNSQRAQLYNQ 1857.0
AS-65585 Human PD-L1 inhibitor V LDYVNRRKMYQ 1485.8
AS-61355 MAGE-3 (271-279) FLWGPRALV 1058,3
AS-62655 NY-ESO-1 (87-111) LLEFYLAMPFATPMEAELARRSLAQ 2869,4
AS-61058 TRP-2 (180-188) SVYDFFVWL 1175,4
AS-64811 TRP-2 (181-188) VYDFFVWL 1088,3
AS-61456 [Asp370]-Tyrosinase (368-376) YMDGTMSQV 1031,2
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