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Myelin Oligodendrocyte Glycoprotein (MOG)

Custom & Catalog Recombinant Proteins

Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys (1-5).

DescriptionSize Reference USD Qty  
Recombinant human MOG (1-125) - 100 µg100 µg AS-55158-100 215.00Order Form
Recombinant human MOG (1-125) - 1000 µg1000 µg AS-55158-1000 1 320.00Order Form
Recombinant human MOG (1-125) - 500 µg500 µg AS-55158-500 858.00Order Form
Recombinant mouse MOG (1-125) - 100 µg100 µg AS-55150-100 215.00Order Form
Recombinant mouse MOG (1-125) - 1000 µg1000 µg AS-55150-1000 1 320.00Order Form
Recombinant mouse MOG (1-125) - 500 µg500 µg AS-55150-500 858.00Order Form
Recombinant rat MOG (1-125) - 100 µg100 µg AS-55152-100 215.00Order Form
Recombinant rat MOG (1-125) - 1000 µg1000 µg AS-55152-1000 1 320.00Order Form
Recombinant rat MOG (1-125) - 500 µg500 µg AS-55152-500 858.00Order Form


Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys (1-5).

The molecular weight of the recombinant MOG is 14.2 kDa.


Figure 1. Mouse rMOG on SDS-PAGE The purified M-rMOG was loaded onto 10-20% Tris-HCl acrylaminde gel at 10 μg/well and resolved at 200V for 60 minutes. Protein markers and the purified M-rMOG (14.23 kDa) are indicated. CL=Crude Cell Lysate, FT=Flow Through, and P=Purified M-rMOG.

Figure 1. The purified rat rMOG was loaded onto 10-20% Tris-HCl gel (10 μg/well) and resolved at 200V for 60 minutes. Protein markers and the purified R-rMOG (14.2 kDa) are indicated. CL=Crude Cell Lysate, FT=Flow Through, and P=Purified R-rMOG.


Figure 1. The purified H-rMOG was loaded onto 10-20% Tris-HCl gel at 10 μg/well and resolved at 200V for 60 minutes. Protein markers and the purified H-rMOG (14.2 kDa) are indicated. CL=Crude Cell Lysate, FT=Flow Through, and P=Purified H-rMOG.


References:


  1. Jayaram Bettadapura et.al. (1998) Journal of Neurochemistry 70 (4): 1593-1599
  2. Alfred R Oliver et al (2003) Journal of Immunology 171:462-468
  3. Hans-Christian Von Budingen et.al. (2001) Journal of Clinical Immunology 21 (3): 155-170
  4. Jerri-Anne Lyons et.al. (1999) European Journal of Immunology 29: 3432-3439
  5. Hans-Christian Von Budingen et.al. (2004) European Journal of Immunology 34: 2072-2083

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