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Neprilysin Assay kit

iD Sensolyte® Assay Kits

Neprilysin (NEP) is a transmembrane metallopeptidase normally expressed by a variety of tissues. It is also known as neutral endopeptidase, and enkephalinase. NEP cleaves peptides at the N-terminal side of hydrophobic amino acid residues and is responsible for the degradation and inactivation of a variety of physiological substrates. NEP is a major extracellular amyloid betapeptide degrading enzyme in the brain. Consequently, targeting NEP is considered a potential therapeutic strategy for the prevention and treatment of Alzheimer's disease. NEP has also been implicated in the pathogenesis of hypertension, diabetes, and cancer.

The SensoLyte® 520 Neprilysin Assay Kit uses a quenched 5-FAM/QXL™ 520 FRET substrate for the detection of NEP activity. The enzyme cleaves the FRET substrate into two separate fragments resulting in the release of 5-FAM fluorescence, which can be monitored at excitation/emission= 490/520 nm. The long wavelength fluorescence of 5-FAM is less interfered by the autofluorescence of components in biological samples and test compounds.

DescriptionSize Reference USD Qty  
SensoLyte® 520 Neprilysin Activity Assay Kit *Fluorimetric* - 1 kit1 kit AS-72223 501.00Add to cart
  • Convenient format: The kit provides ample reagents to perform 100 assays in a 96-well plate format
  • High Speed: The entire process can be completed in one hour
  • Assured Reliability: Detailed protocol and references are provided
  • High Sensitivity: The assay can detect as low as 0.78 mg/ml of active neprilysin

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