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OptimAb™ Anti-Prion Antibody

OptimAb™ catalog antibodies

Prion protein (PrP), also known as CD230, is mainly produced in the nervous sytem. PrP exists as different isoforms, among which the normal PrPc, and the 'scrapie' isoform PrPSc. PrPSc is misfolded and associated to multiple disorders including bovine spongiform encephalopathy, Gerstmann-Straüssler-Scheindker disease (GSS) and the Creutzfeldt-Jakob disease. It contains a much higher beta-sheet content than PrPc, and tends to form protease-resistant aggregates. A hypothesis to support the propoagation of these aggregates and their role in neurodegeneration is that the change from normal PrPc is due to its interaction with PrPSc (conformation conversion hypothesis). 3F4 is reactive to amino acids 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturation). 6D11 reacts with both the PrPc and PrPsc forms. The epitope falls within amino acids 93-109 of PrP.

DescriptionSize Reference USD Qty  
OptimAb Prion (3F4) Monoclonal Antibody, purified - 100 µg100 µg SIG-39620-100 361.00Add to cart
OptimAb Prion (6D11) Monoclonal Antibody, purified - 100 µg100 µg SIG-39810-100 355.00Add to cart

Intented use

Research use only; not to be administered to humans or used for medical diagnostics

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