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Renin Assay Kits

iD Sensolyte® Assay Kits

Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. 

The SensoLyte® Renin Assay Kits provide a convenient assay for high throughput screening of renin inhibitors and for continuous assay of renin activity. 

The SensoLyte® 390 Renin Assay Kit uses a Mc-Ala/Dnp FRET peptide, where the fluorescence of Mc-Ala is quenched by Dnp. Upon cleavage into two separate fragments by renin, the fluorescence of Mc-Ala is recovered, and can be monitored at excitation/emission = 330/390 nm.

The SensoLyte® 520 Renin Assay Kits use a 5-FAM/QXL™520 FRET peptide, where the fluorescence of 5-FAM is quenched by QXL™520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm.

DescriptionSize Reference USD Qty  
SensoLyte® 390 Renin Assay Kit *Fluorimetric* - 1 kit1 kit AS-72039 539.00Add to cart
SensoLyte® 520 Mouse Renin Assay Kit *Fluorimetric* - 1 kit1 kit AS-72161 599.00Add to cart
SensoLyte® 520 Rat Renin Assay Kit *Fluorimetric* - 1 kit1 kit AS-72140 687.00Add to cart
SensoLyte® 520 Renin Assay Kit *Fluorimetric* - 1 kit1 kit AS-72040 599.00Add to cart


• Optimized Sensitivity: - These kits are optimized to detect plasmin, thrombin and cathepsin S activities.
- Best sensitivity ever in renin assays
• Bulk reagents: - Sufficient to perform 100 assays in a 96-well plate format
• High Speed: - The entire assay process can be completed in one hour
• Assured Reliability: - A detailed protocol and references are provided


λ
Ex/Em
(nm)
Biological sample volume Lowest Detection Limit  Kit contains Assay time # of
assays in
96-well plate
Renin Assay Kit
SensoLyte® 520
Rat Renin
Fluorimetric
490/520 40 μl 0.09 ng/well • Renin substrate: 5-FAM/QXL™520 FRET peptide
• 5-FAM, fluorescence reference standard
• Recombinant rat renin
• Assay buffer
• Renin Inhibitor Ac-HPFV- (Sta)-LF-NH2
30-60 min. 100
SensoLyte® 520 Renin
Fluorimetric
490/520 85 μl 0.12 ng/well • Renin substrate: 5-FAM/QXL™520 FRET peptide
• 5-FAM, fluorescence reference standard
• Human recombinant renin
• Assay buffer
• Renin Inhibitor Ac-HPFV- (Sta)-LF-NH2
30-60 min. 100
SensoLyte® 390 Renin
Fluorimetric
330/390 50 µl 1.2 ng/well • Renin substrate: Mc-Ala/Dnp FRET peptide
• Mc-Ala, fluorescence reference standard
• Human recombinant renin
• Assay buffer
• Renin Inhibitor Ac-HPFV- (Sta)-LF-NH2
30-60 min. 100
Sensolyte® 520 Mouse Renin
Fluorimetric
490/520 50 µl 7.7 mM • Mouse renin substrate 5-FAM/QXL™520 FRET peptide
• 5-FAM fluorescence reference standard
• Mouse prorenin
• Assay buffer
• Trypsin activation buffer
• Renin inhibitor
30-60 min. 100
The EGT Ordering System (EOS) is the simplest and easiest way to place your orders including:

 
All oligonucleotides
All Kits & Reagents (including Catalogue Antibodies & Peptides, Real-Time qPCR Mixes, Taq Polymerases, Sensolyte® Assays...)

Please use your Login or Register Now to directly access your customized EOS interface.



You can still place orders by:
orders.anaspec@egt-biotech.com
  When placing your order, please include the following information:
  Contact person purchase order number
  delivery address product description and reference number
  invoice address quotation number
  telephone number  

Related products

Human renin, recombinant AS-72041
Mouse renin, recombinant AS-72174 
Rat renin, recombinant AS-72141

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