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Renin

Custom & Catalog Recombinant Proteins

Renin, a highly specific aspartyl protease, cleaves angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE(Angiotensin Converting Enzyme).1Angiotensin II constricts blood vessels, leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is proposed as a therapeutic target for this disease.2

DescriptionSize Reference USD Qty  
Renin 390 FRET Substrate I - 1 mg1 mg AS-62022 215.00Add to cart
Renin FRET Substrate (5-FAM/QXL™520) - 0.1 mg0.1 mg AS-61872-01 220.00Add to cart
Renin FRET Substrate (5-FAM/QXL™520), rat - 0.1 mg0.1 mg AS-62334-01 220.00Add to cart
Renin FRET Substrate I - 1 mg1 mg AS-24478 220.00Add to cart
Renin Inhibitor Peptide, WFML Peptide, rat - 1 mg1 mg AS-60463-1 181.00Add to cart
Renin Substrate, Angiotensinogen (1-14), human - 1 mg1 mg AS-20631 61.00Add to cart
Renin Substrate, Angiotensinogen (1-14), rat - 1 mg1 mg AS-63857 83.00Add to cart


Renin, a highly specific aspartyl protease, cleaves angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE(Angiotensin Converting Enzyme).1Angiotensin II constricts blood vessels, leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is proposed as a therapeutic target for this disease.2


Reference Name Sequence MM (kDa)
AS-60463-1 Rat Renin Inhibitor Peptide, WFML Peptide Ac-HPFV-(Sta)-LF-NH2 957,3
AS-62022 Renin 390 FRET Substrate I R-E(EDANS)-IHPFHLVIHT-K(DABCYL)-R 2282,7
AS-20631 Renin Substrate, human DRVYIHPFHLVIHN 1760
AS-24478 Renin FRET Substrate I DABCYL-g-Abu-IHPFHLVIHT-EDANS 1798,2
Reference Name Description
AS-60463-1 Rat Renin Inhibitor Peptide, WFML Peptide A specific rat renin inhibitor.
AS-62022 Renin 390 FRET Substrate I This peptide is a renin substrate (angiotensinogen) labeled with EDANS/ DABCYL FRET pair for renin activity studies. The renin-angiotensin system (RAS), acting through type 1 angiotensin (AT1) receptors, is a master regulator of fluid homeostasis.
AS-20631 Renin Substrate, human  
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