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Standard custom peptides

Standard custom peptides

We offer a versatile platform for the synthesis of custom peptides (simple and complex modifications), which cater to several applications including drug discovery research.

Custom peptides specifications

  • Length: 2-60 amino acids.
  • Purity: >95%, >90%, > 85%, >70%, or crude.
    Tip: Purity is assessed by HPLC analysis, and indicates the % of the target peptide in the peptidic mix.
  • Quantity: 1 mg minimum to gram quantities (0.5 mg available for specified modifications) Quantity can be delivered as gross weight or net weight . When absolute quantification is a must, we recommend our Quant-peptides . For less stringent requirements, we offer peptide content based on CHN analysis.
  • Counter-Ion: Default is TFA (Trifluoroacetic Acid) which binds to the peptide N-terminus, and to basic Lys, Arg and His residues. As TFA can be toxic to cells and animals, we also offer an acetate or chloride salt exchange for an additional fee.
  • QC Testing:
    • Mass Spec Analysis
    • % Purity by HPLC, additional testing upon request
    • Water content
    • CHN Analysis
    Inquire for custom analysis
  • Documentation: Mass Spec and HPLC chromatographs, technical data sheet.
  • Format: Lyophilised powder, peptide in solution on request.
    For special format aliquots see Dispensing Service
  • Shipping: Ambient temperature.
  • Lead Time: 3-5 weeks. Highly modified peptides may require longer production times.

Purity vs applications
Applications Blocking and competition assays
Enzyme-substrate studies (quantitative)
Receptor-ligand interaction studies (quantitative)
ELISA and RIA (quantitative)
in vivo/in vitro studies
High precision quantitative proteomics
Western blotting studies (non-quantitative)
Enzyme-substrate studies (non-quantitative)
Phosphorylation studies
Affi nity purifi cation
Production of antibodies for immunisations
Determination of the titer
of antibodies in standard ELISA
Screening purposes
Recommended purity level ≥ 90-95% ≥ 80% ≥ 70% crude

Peptides modifications available

Peptide modification feasibility is dependent on the peptide sequence, properties and desired location. Hence, our technical team will review each request case by case.

Modifications can be of the following types:
> N-terminal
> C-terminal
> Structural
> Conjugation
> UAAD*

N-Terminal C-Terminal Structural Conjugation UAAD* Other
Acetylation (caps charge)
Biotinylation
Fluorescent-dye
Formylation
Myristoylation
Succinylation
Bromoacetylation
DOTA conjugated
Amidation (caps charge)
Biotinylation
Fluorescent-dye
Aldehydes (formylation)
Alcohol group
Hydrazide
Esterification/thiol esters
N-alkyl amidation
Ketones (CMK, FMK)
Cyclisation
Disulfide formation
Hydrocarbon stapling
Lactamation
MAP formations
Thiolactonation
DOTA
BSA
Prenylation
Farnesylation
Geranylation
Peptideoligonucleotide
Alkyne
Azide
Glycosylated
Heavy Isotope
Methylations
Phosphorylation
Sulfonation
Pegylations
Peptidomimetics

*Unnatural Amino Acid (UAADs) can be exploited to enhance the stability, or functionality of a therapeutic target, and can be site specifically incorporated into your synthetic custom peptides.
Examples include post-translational modifications such as the carboxylation of glutamate (forming the UAA- gamma-carboxyglutamate), and hydroxylation of proline (forming the UAA hydroxyproline).


Modifications vs applications
Applications Immunology-related studies Protease activity /inhibitions Protein folding and aggregation studies Protein-protein interactions, membrane-transport/ function, signal transduction etc. Drug delivery, cellular uptake, PK properties, bioactivity, conjugations etc.
Related modifications Biotinylation Formylation Pegylation MAPS KLH/BSA conjugation Alkylamidation Thiolation FRET-based assays Glycosylation Cysteamidation Myristoylation Phosphorylation Peptidomimetics Sulfonation Prenylation Farnesylation Geranylation Methylation Cyclization Br-acetylation Succinylation Stapling

Request a quote

Please complete the Peptide Form to request a quote.
For more information please contact your account Managers or isales@eurogentec.com

 
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